Two sample MR report
HLA-DRB5_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 28 | 0.0508349 | 0.0729281 | 0.4919541 |
| Weighted median | 28 | 0.0561181 | 0.0209070 | 0.0072710 |
| Inverse variance weighted | 28 | 0.0583123 | 0.0156723 | 0.0001987 |
| Simple mode | 28 | 0.0903524 | 0.0408138 | 0.0354790 |
| Weighted mode | 28 | 0.0665311 | 0.0397120 | 0.1054130 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.082174 | 26 | 0.9999148 |
| Inverse variance weighted | 7.093196 | 27 | 0.9999566 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0034026 | 0.0324105 | 0.9171939 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000476 | 0 | TRUE | 0.0381008 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
